AQUA® software

AQUAnalysis™ Software

Images acquired with AQUAsition software are used to localize and quantify various protein biomarker concentrations with unparalleled accuracy and reproducibility using AQUAnalysis software. This software uses proprietary algorithms to identify and localize cellular and sub-cellular (e.g. nucleus, cytoplasm, membrane) compartments of protein biomarkers. Areas of interest are flagged for operator review.

The software’s algorithms and compartmentalization combine to provide an AQUA score reflecting protein concentration in a molecularly defined area—true biomarker localization. Data is presented with significant data stratification, identifying subpopulations not seen with traditional IHC.

AQUAsition™ Software

Our digital imaging software allows the user to accurately identify and image individual tissue fields at multiple wavelengths in both tissue microarrays and whole tissue sections. Signal resolution rivals confocal microscopy while eliminating the visual subjectivity associated with conventional IHC.

Instrumentation

PM-2000

The PM -2000 is a dedicated tissue microarray reader and microscopy-based multiplex imaging device that rapidly analyzes tissue microarray samples and individual tissue slices, generating a quantitative score representing protein expression in the sample while retaining the spatial relationships.

Features Include:

  • incorporates the AQUA® tissue analysis software
  • reproducibly & rapidly measures protein concentrations within subcellular compartments
  • uncompromising quantification capabilities with user-designed multiplexing
  • uses standard histochemistry in tissue microarrays with up to 800 tissue samples per slide
  • proprietary fluorescence-based imaging technology
  • images stored in database for validation and archiving

The ScanScope® FL from Aperio

AQUA analysis is now available for use with fluorescent images acquired by the Aperio ScanScope FL. The partnership between History and Aperio was designed to meet the growing demand for complex analysis of multiple fluorescent biomarkers. This system integrates state of the art software and hardware to provide superior image quality and data analysis/integrity. 

Features include:

  • High Throughput
  • Whole Slide imaging (providing context)
  • Broad Range of Fluorescent applications
  • Image analysis by biological design
  • Database for storage/access of image results/data
  • For use with whole tissues and tissue microarrays
  • Provides continuous expression-  Data analyzed on a continuous scale

 

 Click here for more information on the Aperio /HistoRx partnership