Our Technology

AQUA® technology brings standardization and reproducibility to IHC analysis. Automated fluorescent image acquisition and data analysis use our proprietary software to provide precise quantification of biomarkers of interest, based on the computation of AQUA scores. This can then be correlated with other parameters such as disease progression, clinical outcome, and response to therapy or expression of proteins in alternate pathways.

Quantitative, standardized and reproducible analysis of protein biomarkers in tissue

Imagine combining the best of ELISA and immunohistochemistry (IHC) into one powerful platform. That’s what you get with AQUA technology (Automated Quantitative Analysis).

AQUA is an automated image analysis platform that brings objective results to the multiparametric analysis of protein in tissues, providing results that are:

  • Quantitative—AQUA technology quantitates protein expression within subcellular compartments in tissue automatically and with a high degree of precision similar to ELISA.
  • Standardized and reproducible—imaging and scoring occurs through proprietary software-enabled analysis
  • Discretely localized—maintains tissue morphology similar to IHC, but without its inherent subjectivity.
  • Ease of use—through automation and simple operation
  • High resolution—superior to traditional chromagen-based immunohistochemical analysis.
  • Multiplex-capable—for complex analyses.

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AQUA technology utilizes fluorescence-labeled antibodies and molecular markers to maximize dynamic range and sensitivity, the foundation for computing an AQUA score. AQUA scores enable truly quantitative assessment of protein biomarkers in fixed tissue, which can then be correlated with other parameters such as disease progression, clinical outcome, response to therapy or expression of proteins in alternate pathways.